"Researchers say the findings may help explain why some sedentary people can eat a high-fat diet without suffering the artery-clogging consequences while others who exercise regularly still suffer from high cholesterol levels. Eating a healthy, low-fat diet and regular exercise can help the vast majority of people maintain healthy cholesterol levels. But researchers say their results show that some people may be born with genes that make them naturally more sensitive or resistant to dietary cholesterol, whether they're a couch potato or a marathon runner." (reference)

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